Snakes on a Plane is a movie starring Samuel L. Jackson set for release on August 18, 2006. It is literally about snakes being on a plane during a flight from Hawaii to Los Angeles. It was announced in 2005.
After the announcement of the movie, the movie quickly became a fad on Board 8, GameFAQs, and many other websites, due to its uncreative title (and because a star like Jackson was starring in such a doomed film). There are many references to the movie, as well as a message board relating to the fad.
ENOUGH IS ENOUGH! I've had it with these muthafuckin snakes on this muthafuckin plane!
Surprisingly, the film's creators embraced this cult following wholeheartedly, even going so far as to shoot extra scenes, including the above line which was created by fans as a parody of Jackson's usual movie persona, and the film turned out to be actually very good, and an example of pure entertainment. There was no attempt at a deep plot, nothing made to please the critics, they just gave the fans exactly what they wanted- a load of mother****ing snakes on a mother****ing plane.
Still pretty much bombed at the box office though. Probably got beaten by Generic Gross-Out Comedy #673 or something. Some people have no taste.